Natural Factors PQQ-10 30 Softgels

Studies show that PQQ raises blood flow to the cerebral cortex. This is the part of your brain that helps with attention, thinking, and memory. This supplement also seems to prevent memory problems in older people

Nice to see a combination of PQQ and CoQ10 in one pill, but these are massively large. Takes some getting used to swallowing them; they're the largest pill I've ever had before. The Q10 in here is ubiquinone, but unfortunately doesn't describe its formulation, which according to recent papers is critical to understanding its bioavailability. Given the lack of info, I can only assume it is a less effective than other fancier ones and ubiquinol. On the upside, you get BioPQQ with it all in one swallow.(See "Coenzyme Q10, Ageing and the Nervous System: An Overview" by Mantle et al. in Antioxidants 2022, 11(1), 2, which notes "That the relative bioavailability of ubiquinone and ubiquinol forms of CoQ10 depends on its CoQ10 crystal dispersion status and carrier ... MoreNice to see a combination of PQQ and CoQ10 in one pill, but these are massively large. Takes some getting used to swallowing them; they're the largest pill I've ever had before. The Q10 in here is ubiquinone, but unfortunately doesn't describe its formulation, which according to recent papers is critical to understanding its bioavailability. Given the lack of info, I can only assume it is a less effective than other fancier ones and ubiquinol. On the upside, you get BioPQQ with it all in one swallow.(See "Coenzyme Q10, Ageing and the Nervous System: An Overview" by Mantle et al. in Antioxidants 2022, 11(1), 2, which notes "That the relative bioavailability of ubiquinone and ubiquinol forms of CoQ10 depends on its CoQ10 crystal dispersion status and carrier oil/excipient composition", and even more annoyingly, "that there may be groups of patients with restricted ability to absorb this compound irrespective of formulation type." Or see his older "Bioavailability of Coenzyme Q10: An Overview of the Absorption Process and Subsequent Metabolism" 2020 paper, both of which cite "Bioavailability of coenzyme Q10 supplements depends on carrier lipids and solubilization" by Lopez-Lluch et al. in 2019.)

This is a synergistic combination of PQQ with Q10. In order to notice the effect of PQQ/Q10, the dosage must be correct. I think the dose is already good but take an extra 100mg Q10 next to this. This is quite an energizing combination. To my surprise I wake up much earlier and have more vivid dreams. With cycling I notice that my heartrate after a strenuous effort drops much faster then before.